genes encoding – Communicable Diseases Research

Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control

Research article

Published on 2022-12-012022-10-05
Journal: Biochimica et biophysica acta. Molecular basis of
[Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans

Article

Published on 2022-11-012022-11-15
Journal: Molecular genetics and genomics : MGG
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses
[DOI] 10.1007/s00438-022-01954-7 PMC 바로가기

Comparison of the SARS-CoV-2 BD Veritor Nasal Antigen Test with Nasopharyngeal Reverse Transcription-PCR in Symptomatic Patients

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infections

Article

Published on 2022-10-172022-11-16
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus
[DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기

Friend or foe: RIG- I like receptors and diseases

Article

Published on 2022-10-012022-11-15
Journal: Autoimmunity reviews
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease

주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다

Review

Published on 2022-09-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors Toll-like receptors. understanding variants of concern Variation viral infection viral infections VOCs
[DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review

The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals

Research

Published on 2022-07-022022-10-05
Journal: The Pharmacogenomics Journal
[Category] 유전자 메커니즘,

[키워드] alleles chromosome 10 clinically compounds CYP2C8 CYP2C9 cytochrome P450 enzyme drug drugs exhibit genes encoding Haplotype influence Linkage disequilibrium locus metabolism reduced therapeutic doses Toxicity Variation
[DOI] 10.1038/s41397-022-00284-6 [Article Type] Research

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

Research

Published on 2022-04-252022-10-05
Journal: Nature Microbiology
[Category] 변종, 유전자 메커니즘,

Spread of hypervirulent multidrug-resistant ST147 Klebsiella pneumoniae in patients with severe COVID-19: an observational study from Italy, 2020-21

Observational Study

Published on 2022-03-312022-10-05
Journal: Journal of Antimicrobial Chemotherapy
[Category] Coronavirus, 임상,

Diagnostic performance and clinical feasibility of a novel one-step RT-qPCR assay for simultaneous detection of multiple severe acute respiratory syndrome coronaviruses

다중 심각한 급성 호흡기 증후군 코로나 바이러스의 동시 검출을위한 새로운 1 단계 RT-QPCR 분석의 진단 성능 및 임상 적 타당성

Original Article

Published on 2022-02-092022-09-10
Journal: Archives of Virology
[Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, 치료기술, 치료제,

[키워드] Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis can be used caused cell culture supernatants Chain Reaction circulating variant clinical outcomes clinical sample coronavirus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CoVs Critical cross-reaction Diagnosis early diagnosis evaluated event feasibility genes encoding healthy individuals human CoV human CoVs humans IMPROVE in vitro infect Laboratory laboratory diagnosis limit of detection majority membrane mild respiratory symptoms mRNA multiplex RT-qPCR nasal swab Other other coronaviruses Other respiratory viruses patients with COVID-19 polymerase chain polymerase chain reaction Protein qPCR assay Quantitative reaction respiratory respiratory infection Respiratory samples respiratory symptoms respiratory viruses reverse transcription RNA RT-qPCR SARS-CoV-2 SARS-like CoV SARS-like CoVs SARS-related CoV severe acute respiratory syndrome Coronavirus sputum samples supplementary material TCID Transmission zoonotic origin
[DOI] 10.1007/s00705-022-05383-0 PMC 바로가기 [Article Type] Original Article